The (second) statistical analysis based on all animals did not detect any differences in haematological and clinical biochemical parameters. The 80th percentile annual average concentrations for amprolium in leachate at 100 cm depth were all below 0.001 μg/L for all relevant scenarios as identified by FEEDAP guidance (EFSA, The following values are used for the assessment of amprolium: a PECA GLP‐compliant terrestrial plant seedling emergence and growth study following OECD 208 was performed with six plant species; four dicotyledons (A GLP‐compliant earthworm reproduction study following OECD 222 was performed with the earthworm A GLP‐compliant nitrogen transformation study following OECD 216 was performed in a natural sandy loam soil.The soil nitrogen transformation rate was determined at 7, 14, and 28 days after application.
In ASTs 2 and 3, the least square means of IUC were tested against UUC and IT separately.Oocyst excretion about 1 week after inoculation indicated successful A significant reduction of intestinal lesion scores (duodenum and caecum) by the COXAMAverage daily gain in the IT group was significantly improved by the anticoccidial treatment as seen by a comparison of the IUC and IT groups in all three ASTs. There are a lot of products out there that chicken people use "off label". a,b,c, Means in a column within a study with different superscript are significantly different (p ≤ 0.05). a,b,c Means within a column within a study with different superscript are significantly different (p ≤ 0.05). * Means within a column with * are significantly different to IT group (p ≤ 0.05). The values reported represent the sum of lesion scores specific to * Means within a column with * are significantly different to IUC group (p ≤ 0.05). Consequently, according to Regulation (EC) No 429/2008In Phase I a total residues approach is taken, meaning that the predicted environmental concentrations (PECs) is calculated, based on the assumption that the additive is excreted 100% as parent compound.The physicochemical properties of amprolium are summarised in Table No information is available on the hydrolysis or biodegradation of amprolium in water.A Good Laboratory Practice (GLP)‐compliant soil adsorption/desorption study following OECD guideline 106 batch equilibrium method was performed with five soils of differing properties using non‐radiolabelled amprolium.A GLP‐compliant soil biodegradation study following OECD guideline 307 was performed with four soils of differing properties using non‐radiolabelled amprolium.The PECs were calculated according to the FEEDAP technical guidance for assessing the safety of feed additives for the environment (EFSA, The input values used for initial PEC calculations were: 125 mg/kg feed, molecular weight (MW) = 315.24, vapour pressure (VP(Pa)) = 4.928E‐15, Solubility (SOL) = 540,320 mg/L, DTThe Phase I PEC trigger values were exceeded. Meaning, they were made for other animals, such as cattle, goats, horses, etc, but work just fine on chickens. However, the original data used in these assessments were not provided and the literature review covering the subsequent period was not made.
EMEA/MRL/767/00‐FINAL. a,b,c Means within a column within a study with different superscript are significantly different (p ≤ 0.05). a,b,c Means within a column within a study with different superscript are significantly different (p ≤ 0.05). a,b,c Means in columns with different superscript are significantly different (p ≤ 0.05). Myth #3: I do not want residual drugs in my meat or eggs. a,b,c, Means in a column within a study with different superscript are significantly different (p ≤ 0.05). * Means within a column with * are significantly different to IT group (p ≤ 0.05). 2 No statistical analysis was applied to the periods reported. a,b,c, Means in a column within a study with different superscript are significantly different (p ≤ 0.05). In all three trials the body weight gain of the UUC groups exceeded significantly that of IT groups. 2 NOAEL. 1 Results of trials 1 and 3 refer to daily feed intake; results of trial 2 refer to cumulative feed intake (day 0–35). a,b,c Means in columns with different superscript are significantly different (p ≤ 0.05).
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